PEPTIDE-MODIFIED PAMAM-BASED BONE-TARGETING RNA DELIVERY SYSTEM

Peptide-modified PAMAM-based bone-targeting RNA delivery system

Abstract Background Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopausal women.Traditional anti-osteoporotic therapies, though widely prescribed, are limited by a lack of cell- or tissue-specific targeting ability and effectiveness without side effects.Gene therapy is rapidly

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Biological function of activation-induced cytidine deaminase (AID)

Activation-induced Cytidine Deaminase (AID) is an essential regulator of B cell diversification, but its full BROWN RICE SPIRALS range of action has until recently been an enigma.Based on homology, it was originally proposed to be an RNA-editing enzyme, but so far, no RNA substrates are known.Rather, it functions by deaminating cytidine, and in thi

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